Posts Tagged ‘broccoli’

System Effected by Possible Side Effects of Sorafenib

Gastrointestinal

Gastrointestinal (GI) side effects including diarrhea (43%), increased lipase (41%), increased amylase (30%), nausea (23%), anorexia (16%), vomiting (16%), and constipation (15%) have been reported. Common side effects have included mucositis, stomatitis, (including dry mouth and glossodynia), dyspepsia, and dysphagia. Uncommon side effects have included pancreatitis, GI reflux, and gastritis. In addition, GI perforation has been reported in less than 1% of patients receiving sorafenib and not always associated with apparent intra- abdominal tumor.

Dermatologic

Dermatologic side effects including rash/desquamation (40%), Hand-foot skin reaction (30%), alopecia (27%), pruritus (19%), and dry skin (11%) have been reported. Very common side effects have included erythema. Common side effects have included exfoliative dermatitis, acne, and flushing. Scalp dysesthesia and subungual splinter hemorrhages (characterized by straight black or red lines under the nails) have been reported. Uncommon side effects have included folliculitis, eczema, and erythema multiforme. Three cases of keratoacanthomas and two cases of sorafenib-induced eruptive melanocytic lesions have also been reported.

Cardiovascular

Cardiovascular side effects including hypertension (17%) have been reported. Uncommon side effects have included hypertensive crisis, congestive heart failure, myocardial ischemia, and/or infarction. Cardiac failure, thromboembolism, and arrhythmia have been reported infrequently.

Hematologic

Hematologic side effects including Hypoalbuminemia (49%), hemorrhage (15%) (i.e., gastrointestinal, respiratory tract and rarely cerebral hemorrhage) have been reported. Common side effects have included anemia and thrombocytopenia. Uncommon side effects have included abnormal international normalized ratio (INR) results. Cases of erythrocytosis have also been reported.

Respiratory

Respiratory side effects including dyspnea (14%) and cough (13%) have been reported. Common side effects have included hoarseness. Uncommon side effects have included rhinorrhea.

Nervous System

Nervous system side effects including sensory neuropathy (13%) and headache (10%) have been reported. Common side effects have included tinnitus. Cerebral hemorrhage, transient ischemic attack, and reversible posterior leukoencephalopathy have also been reported infrequently.

Musculoskeletal

Musculoskeletal side effects including joint pain (10%) have been reported. Common side effects have included arthralgia and myalgia.

Immunologic

Immunologic side effects have very commonly included leukopenia and lymphopenia. Common side effects have included neutropenia.

Hypersensitivity

Hypersensitivity side effects including skin reactions and urticaria have been reported.

Metabolic

Metabolic side effects including weight loss (10%), transient increases in transaminases, and hypophosphatemia have been commonly reported. Uncommon side effects have included dehydration, hyponatremia, transient increases in alkaline phosphatase, increased bilirubin (including jaundice), and hypothyroidism.

Psychiatric

Psychiatric side effects have commonly included depression.

Genitourinary

Genitourinary side effects have commonly included erectile dysfunction. Uncommon side effects have included gynecomastia.

Renal

Renal side effects including acute renal failure have been reported infrequently.

Hepatic

Hepatic side effects including liver dysfunction have been reported in at least 10% of patients.

Other

Other side effects including fatigue (37%) and abdominal pain (11%) have been reported. Very common side effects have included asthenia and pain (including mouth, bone, and tumor pain). Common side effects have included decreased appetite, influenza-like illness, and pyrexia. Uncommon side effects have included infection.

Broccoli To The Rescue

There are naturally occurring substances that block precisely this undesired NF-KB pathway and thus make the dangerous cells vulnerable: vegetables from the cruciferous family such as broccoli and cauliflower possess a high content of sulforaphane, an anti-cancer compound.

The experiments show that sulforaphane prevents the activation of the NF-kB pathway by sorafenib. The combination treatment reinforces the effect of sorafenib without causing additional side effects.

The invasive potential of cancer cells was prevented – metastasis was completely blocked in cell culture experiments. “We assume that nutrition may be a suited approach to break therapy resistance of cancer stem cells and thus make tumor treatment more effective,” Professor Herr suggested

You Must Remember, the medical advice from your doctor, leaves out one fact-food is medicine.

Broccoli’s green profit potential doesn’t come from the sale of the vegetable. It is a compound derived from broccoli that could prevent and treat breast cancer, by targeting cancer stem cells. This is according to a new study from researchers at the University of Michigan Comprehensive Cancer Center. The green vegetable can turn a green profit for pharmaceutical companies.

Broccoli The Green Gold Mine

Broccoli could be the green gold mine, both for health and the wealth of pharmaceutical companies.

The study tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures. Researchers found sulforahane targeted and killed the cancer stem cells and prevent new tumors from growing.

It seems ironic that women who go on vegetable juicing, high whole food diets have a very positive effect on their tumors markers. Yet, doctors say diet isn’t the cause and has nothing to do with this condition. Yet, when it can be pharmaceutical enhanced it is now a treatment.

“Sulforahane has been studied previously for its effects on cancer, but this study shows that their benefit is in inhibiting the breast cancer stem cells. This new insight suggests the potential of sulforaphane or broccoli extract to prevent or treat cancer by targeting the critical cancer stem cells.” said study author Duxin Sun, PhD., associate professor of pharmaceutical sciences at the U-M College of Pharmacy and researcher with U-M Comprehensive Cancer center. The University of Michigan is one of the top universities involved in these kinds of studies. 

Current chemotherapies do not work against stem cells, which is why cancer recurs and spreads. Researches believe that eliminating the cancer stem cells is the key to controlling cancer.

Broccoli in Nature

The message from the drug company is that broccoli in nature will not supply the concentrations of sulforaphane needed. Prior research suggests the concentrations needed by the body from the broccoli extract to impact cancer can be absorbed by the body from the broccoli extract.

Patients are not encouraged to add sulforaphane supplement to their diet at this time. Long term side effects aren’t known. Researches are currently developing a method to extract and preserve sulforaphane. They will be developing a clinical trial to test sulforaphane as a prevention and treatment for breast cancer.

Broccoli Reality

Broccoli reality is based on common sense. These studies may be innovative, collaborated and reliable, but they still miss the boat. Our food supply is versatile, it feeds, nourishes, and substances us. Why wouldn’t we start with the basics provided for us in the plants, fruits, and herbs. What science has done is take everything natural down to their level. Where they turn it into powders, liquids, capsules and find ways to disperse it.

Their green solutions come with a dollar sign. The energy, clarity, and health comes from the broccoli in it’s whole form. The phytochemicals work synergistically for you, when consumed as mother nature intended.